Opportunstic Infections in HIV

CD4 ct <500: seborrheic dermatitis; oral hairy leukoplakia; Kaposi's sarcoma; recurrent oral, esophageal or vaginal candidiasis; recurrent bacterial infections; pulmonary and extrapulmonary TB; HSV, VZV.

CD4 ct<200: PCP* (now called pneumocystis jirovecii) , toxoplasma*, cryptococcus, histoplasma**, coccidiodes, bartonella

CD4 ct <50-100: CMV, disseminated MAC*, invasive aspergillosis, bacillary angiomatosis,CNS lymphoma, PML

*requires prophylaxis:

--PCP, cd4 <200, TMP-SMX (or dapsone, atovaquone or pentamadine)

--toxo, cd4<100, TMP-SMX (or dapsone + leucovorin +pyrimethamine)

--MAC, cd4<50, azithromycin (or clarithromycin or rifabutin)

--Histoplasma only in endemic areas, cd4 <150, itraconazole

see IDSA link for Guidelines for treatment and prevention of OIs in HIV+ patients:

(Victoria Kelly MD, 11/8/10)